Platform Commercial Milestones: HPAE-Based Transfection Reagents
The BrPERfect® reagent portfolio was fully invented, validated and quality-system built in-house by Branca Bunús as industrial proof-of-concept for our HPAE platform’s manufacturability and real-world functionality. Following our strategic partnership launch with PolyGene Biotech, all global manufacturing, scale-up, customer supply and technical support operations have transitioned to our exclusive commercial partner. All product specifications, pricing, sample requests and process support are managed fully via PolyGene’s dedicated website.
Core reagent platform benefits
Superior transfection efficiency paired with preserved cell viability for sensitive biomanufacturing workflows
Simple, rapid mixing protocols with stable polyplex complexes holding activity for a minimum of 3 hours at ambient temperature
Fully scalable from small academic lab scale to full GMP bioproduction volumes
Animal-component-free chemically defined formulations with complete biodegradation profiles
Validated for AAV, lentivirus, recombinant mAb and transient protein production workflows
Full regulatory documentation suite including FDA Type II DMF for GMP-grade production materials
Invented by Branca Bunús, supplied globally by PolyGene
BrPERfect® for Virus
Optimised HPAE transfection reagent for suspension and adherent HEK293 transient AAV and lentiviral vector manufacturing.
BrPERfect® for Protein
Transfection formulation for high-yield recombinant antibody and protein expression in CHO / HEK293 cell lines.
TransPi™ Mate
Research-grade adherent cell transfection reagent for routine lab gene expression and screening assays.
Strategic partnership
Branca Bunús Ltd and PolyGene Biotech operate as independent entities under a long-term strategic partnership, founded by the HPAE technology inventor Professor Wenxin Wang. BrB retains the ownership of HPAE platform intellectual property and leads therapeutic pipeline development; PolyGene holds exclusive global manufacturing, distribution and commercialisation rights for all transfection reagent lines.
Return to HPAE Platform Science
Branca Bunús is first and foremost a platform and gene medicine innovator.